Custom Peptides
Cayman Chemical 7 Z-Pentacosen 10mg
An unsaturated cuticular hydrocarbon that acts as a contact sex pheromone in Drosophila; may stimulate copulation either by itself at high concentrations or when combined with other alkenes; increases in Drosophila females immediately after copulation
Cayman Chemical TrIfolIrhIzIn 10mg
A flavonoid with anticancer and vasorelaxant activities; induces the accumulation of LC3 puncta in HCT116 and SW620 cells, as well as inhibits proliferation of B16/F10 murine melanoma and human A2780 ovarian and MKN45 gastric cancer cells at 20 µM; induces intratumor apoptosis and necrosis and reduces tumor weight and volume in a colorectal cancer mouse xenograft model; induces relaxation in precontracted isolated mouse aortic rings in a β2-adrenergic receptor-independent manner from 0.2-20 UG/ml
Cayman Chemical PIrInIxIc ACD AmInothIazl 10mg
A dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 µM, respectively); reduces the synthesis of PGE2 and LTC4 during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response
Cayman Chemical 1Docosahexaenoyl2hydroxys 10mg
A lysophospholipid; has been found in shark liver extract; decreases LPS-induced increases in the levels of TNF-α and IL-6 in RAW 264.7 cells; decreases LPS-induced NO production in RAW 264.7 cells from 12-200 µM; inhibits zymosan A-induced plasma leakage into the peritoneum in a mouse model of peritonitis from 15-500 UG/kg
Cayman Chemical MetrIzamIde 10mg
A non-ionic contrast agent; does not induce EEG abnormalities in rabbits at 0.1 ml/kg of a 370 mg I/ml solution; has been used as a solute in gradient centrifugation applications
Cayman Chemical 9 10DImethoxypTRocarpn3O 10mg
A flavonoid glycoside with anti-inflammatory activity; inhibits LPS-induced NO production in RAW 264.7 macrophages (EC50 = 14.7 µM)
Cayman Chemical Etongestrel 10mg
A progesterone and androgen receptor antagonist (IC50s = 0.51 and 0.12 nM for isolated rabbit uterus and rat prostate cells, respectively) and an active metabolite of desogestrel; increases endometrial and myometrial vascularization, uterine weight, and uterine artery length, as well as decreases the number of hormone-secreting corpus luteal glands in non-ovariectomized guinea pigs when administered subcutaneously as a 1 mm sustained-release pellet
Cayman Chemical FezolIntnt 10mg
An NK3 receptor antagonist (IC50 = 20 nM); decreases plasma levels of LH in castrated cynomolgus monkeys at 5 mg/kg; prevents increases in body weight and food intake but does not affect uterine weight or plasma levels of estradiol, FSH, progesterone, or testosterone in ovariectomized rats at 10 mg/kg; inhibits increases in skin temperature but not core temperature, indicating regulation of hot flash-like symptoms, in ovariectomized rats at 3 or 10 mg/kg
Cayman Chemical CaspofungInacetate 10mg
An echinocandin antifungal; active against 3,959 Candida clinical isolates (MIC90 = 1 UG/ml), including isolates resistant to fluconazole or itraconazole, as well as 38 Aspergillus clinical isolates, including A. flavus, A. niger, A. terreus, and A. fumigatus (MICs = 50 = 0.6 nM in C. albicans membrane preparations); increases survival in mouse models of disseminated candidiasis or aspergillosis
Cayman Chemical 5-trns Fluprostenol 10mg
A potential impurity in commercial preparations of fluprostenol
Cayman Chemical Methylcarbamyl PAF C-16 10mg
Methylcarbamoyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.{613,4944} It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in PRP.{613} In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamoyl PAF C-16 cause the induction of c-myc and c-fos and the activation of MAPK.{4944} Methylcarbamoyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.{4944}
Cayman Chemical ADBPINCA pentnoIc ACD met 10mg
An expected compound produced by phase I metabolism of ADB-PINACA in vivo, based on the metabolism of comparable alkylindole CBs
Cayman Chemical Swerosde 10mg
An iridoid glycoside; inhibits LPS-induced production of PGE2 and ROS in mouse RAW 264.7 macrophages at 40 µM; inhibits the growth of U937 lymphoma and HL-60 leukemia cells (IC50s = 67.92 and 62.58 µM, respectively); reduces tumor growth in an HL-60 mouse xenograft model at 50 mg/kg; reduces weight gain and serum total cholesterol, triglyceride, LDL-C, and FFA levels in a mouse model of obesity induced by a HFD at 120 mg/kg
Cayman Chemical LIfItegrastsodIum salt 10mg
An inhibitor of the LFA-1/ICAM-1 interaction; binds to LFA-1 and blocks the adhesion of Jurkat T cells or HuT 78 cells to ICAM-1 (IC50s = 2.98 and 9 nM, respectively) and inhibits secretion of various cytokines from these cells; increases tear production in dogs with idiopathic keratoconjunctivitis sicca; topical application inhibits LFA-1-dependent neutrophil recruitment to the eye in mouse models of contact lens-associated corneal inflammation induced by corneal abrasion and tobramycin-killed bacteria
Cayman Chemical SCIADOPITYSIN 10MG
A biflavonoid with diverse biological activities; reduces Aβ42-induced cytotoxicity in PC12 cells (EC50 = 9.84 μM); decreases methylglyoxal-induced insulin secretion, production of ROS, cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells from 0.1-10 μM; inhibits P-gp (IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells; inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss